2024

• Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.
  Tamura T, Irie T, Deguchi S, Yajima H, Tsuda M, Nasser H, Mizuma K, Plianchaisuk A, Suzuki S, Uriu K, Begum MM, Shimizu R, Jonathan M, Suzuki R, Kondo T, Ito H, Kamiyama A, Yoshimatsu K, Shofa M, Hashimoto R, Anraku Y, Kimura KT, Kita S, Sasaki J, Sasaki- Tabata K, Maenaka K, Nao N, Wang L, Oda Y; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ikeda T, Saito A, Matsuno K, Ito J, Tanaka S, Sato K, Hashiguchi T, Takayama K, Fukuhara T.
  Nat Commun. 2024 Feb 8;15(1):1176. doi: 10.1038/s41467-024-45274-3.
  PMID: 38332154


• Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.
  Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, Begum MM, Uriu K, Mizuma K, Nao N, Kojima I, Tsubo T, Li J, Matsumura Y, Nagao M, Oda Y, Tsuda M, Anraku Y, Kita S, Yajima H, Sasaki-Tabata K, Guo Z, Hinay AA Jr, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Nasser H, Jonathan M, Putri O, Kim Y, Chen L, Suzuki R, Tamura T, Maenaka K, Irie T, Matsuno K, Tanaka S, Ito J, Ikeda T, Takayama K, Zahradnik J, Hashiguchi T, Fukuhara T, Sato K; Genotype to Phenotype Japan (G2P‐Japan)
  Consortium.Microbiol Immunol. 2024 Sep;68(9):305-330. doi: 10.1111/1348-0421.13165. Epub 2024 Jul 4.
  PMID: 38961765


• Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants.
  Yajima H, Nomai T, Okumura K, Maenaka K; Genotype to Phenotype Japan (G2P- Japan) Consortium; Ito J, Hashiguchi T, Sato K.
  mBio. 2024 Sep 16:e0322023. doi: 10.1128/mbio.03220-23. Online ahead of print.
  PMID: 39283095


• Protocol to identify the ligand binding site of Mincle using NMR spectroscopy.
  Furukawa A, Kumeta H, Saitoh T, Maenaka K
  STAR Protoc. 2024 Jun 21;5(2):102996. doi: 10.1016/j.xpro.2024.102996. Epub 2024 Apr 3.
  PMID: 38573861


• Chlamydia trachomatis L2 434/Bu readily activates glycolysis under hypoxia for efficient metabolism.
  Li R, Zhang S, Otsuguro S, Nagao M, Matsuda A, Thapa J, Okubo T, Maenaka K, Higashi H, Yamaguchi H.Biochem Biophys Res Commun. 2024 Aug 6;736:150461. doi: 10.1016/j.bbrc.2024.150461. Online ahead of print.
  PMID: 39128263


• Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies.
  Tadokoro T, Tsuboi H, Nakamura K, Hayakawa T, Ohmura R, Kato I, Inoue M, Tsunoda SI, Niizuma S, Okada Y, Otsuguro S, Maenaka K. Protein Sci. 2024 Jul;33(7):e5084. doi: 10.1002/pro.5084.
  PMID: 38923711


• Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
  Ozawa T, Ikeda Y, Chen L, Suzuki R, Hoshino A, Noguchi A, Kita S, Anraku Y, Igarashi E, Saga Y, Inasaki N, Taminishi S, Sasaki J, Kirita Y, Fukuhara H, Maenaka K, Hashiguchi T, Fukuhara T, Hirabayashi K, Tani H, Kishi H, Niimi H.Structure. 2024 Mar 7;32(3):263-272.e7. doi: 10.1016/j.str.2023.12.013. Epub 2024 Jan 15.
  PMID: 38228146


• Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination.
  Fukuhara H, Yumoto K, Sako M, Kajikawa M, Ose T, Kawamura M, Yoda M, Chen S, Ito Y, Takeda S, Mwaba M, Wang J, Hashiguchi T, Kamishikiryo J, Maita N, Kitatsuji C, Takeda M, Kuroki K, Maenaka K. Elife. 2024 Jul 24;12:RP88929. doi: 10.7554/eLife.88929.
  PMID: 39046448


• Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1.
  Yajima H, Anraku Y, Kaku Y, Kimura KT, Plianchaisuk A, Okumura K, Nakada-Nakura Y, Atarashi Y, Hemmi T, Kuroda D, Takahashi Y, Kita S, Sasaki J, Sumita H; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ito J, Maenaka K, Sato K, Hashiguchi T.
  Nat Commun. 2024 Oct 7;15(1):8574. doi: 10.1038/s41467-024-52808-2.
  PMID: 39375326






• BSL3クライオ電子顕微鏡を用いた感染症創薬・ワクチン研究とその展望
  前仲勝実、福原秀雄、Hisham Dokainish、安楽佑樹、喜多俊介
  実験医学増刊号 『All JAPANで挑む アカデミア創薬研究の最新戦略』 (2024年1月) 編集：善光龍哉（AMED），辻川和丈（大阪大学）
• 中分子創薬が直面する課題とその克服に向けて
  Miyachi H, Maenaka K
  Yakugaku Zasshi. 2024;144(5):527-528. doi: 10.1248/yakushi.23-00191-F.
  PMID: 38692928